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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36542 | Prostaglandin A2 | Medullin | |
PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some anti... | |||
T36158 | 8-iso Prostaglandin A2 | 8-iso Prostaglandin A2 | |
8-iso Prostaglandin A2 is an isoprostane produced by the nonenzymatic oxidation of arachidonic acid. | |||
T7948 | HPGDS inhibitor 2 | GSK-2894631A | PGE Synthase |
HPGDS inhibitor 2 (GSK-2894631A) is a potent, selective hematopoietic prostaglandin D synthase (h-pgds) inhibitor, IC50 = 9.9 nm. | |||
T7652 | AM211 | AM211 free acid | Prostaglandin Receptor |
AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2) | |||
T1562 | Rebamipide | Proamipide,OPC12759 | Free radical scavengers , COX , Prostaglandin Receptor |
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis ... | |||
T67766 | HHS-0701 | Others | |
HHS-0701 is a sulfur-triazole exchange (SuTEx) ligand. HHS-0701 is a potent inhibitor of tyrosine-reactive prostaglandin reductase 2 (PTGR2). HHS-0701 can block PTGR2 metabolism of the lipid substrate 15-Keto-PGE2. | |||
T35610 | 2,5-dimethyl Celecoxib | Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor | |
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... | |||
T77601 | WAY-298630 | GPR | |
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in studies of rhinitis, COPD, rheumatoid arthritis, eczema and con... | |||
T6424 | Bromfenac Sodium | AHR 10282B,Bronuck,AHR 10282R | COX |
Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. | |||
T1804 | HPGDS inhibitor 1 | HPGDS-inhibitor-1 | PGE Synthase |
HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM. | |||
T0839 | Ketoprofen | RP-19583 | Apoptosis , COX , MRP |
Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenas... | |||
T36536 | SH-42 | ||
SH-42 is an inhibitor of 24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dos... | |||
T1468 | Lornoxicam | Ro 13-9297,Chlortenoxicam,TS110 | COX , Endogenous Metabolite |
Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam co... | |||
T6S1027 | Tussilagone | Others | |
1. Tussilagone inhibits dendritic cell function through the induction of heme oxygenase-1. 2. Tussilagone has anti-cancer activity, might be a potential chemotherapeutic agent for the prevention and treatment of human co... | |||
T2966 | Beta-Sitosterol | Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost | Apoptosis , Lipase , Endogenous Metabolite |
Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun... | |||
T34165 | Prostalene | RS 9390,RS9390,RS-9390,Synchrocept | |
Prostalene is a prostaglandin F(2)alpha analogue used in pregnancy. | |||
T41073 | Pexopiprant | ||
Pexopiprant, a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2) with a K i value less than 100nM, is a valuable compound for asthma research. | |||
T13488 | 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide | 2-_E-2-decenoylamino_ethyl_2-_cyclohexylethyl__sulfide | Prostaglandin Receptor |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound known to inhibit stress-induced ulcers, effectively maintaining the levels of phospholipase A2 and prostaglandin E2 in rats subjected to water immersio... | |||
T61261 | Isofezolac | ||
Isofezolac (LM 22070) is a non-steroidal anti-inflammatory drug (NSAID) known for its potent inhibition of prostaglandin-synthetase. This compound exhibits notable anti-inflammatory and antipyretic properties [1] [2]. | |||
T15503 | HQL-79 | Others | |
HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 μM and IC50: 6 μM). It also shows no ... |